21CHY535 PHARMACEUTICAL CHEMISTRY-
Unit I-
Introduction: Common diseases – Infective diseases – insect-borne, air-borne and waterborne – hereditary diseases, Terminology – drug, pharmacology, anti-metabolites, Absorption of drugs – routes of administration of drugs, factors affecting absorption, Assay of drugs – chemical, biological, immunological assays, LD50 and ED50 therapeutic index, drug dosage.
Unit II-
Designation of drugs: Designation of drugs based on physiological action; Definition and two examples with structure each of Anesthetics-General and local, Analgesics – Narcotic and synthetic, Antipyretics and anti-inflammatory agents, Antibiotics – penicillin, streptomycin, chloramphenicol, tetracycline, Antivirals, AIDS – symptoms, prevention, treatment, Cancer and neoplastic agents.
Unit III-
Common body ailments: Diabetes – Causes, hyper and hypoglycemic drugs – Psychedelic drugs, hypnotics, sedatives (barbiturates, LSD) – Blood pressure – Systolic & Diastolic Hypertensive drugs – Cardiovascular drugs – anti arrhythmic, antianginals, vasodilators – CNS depressants and stimulants – Lipid profile – HDL, LDL cholesterol, lipid lowering drugs.
Unit IV-
Health promoting medicines: Nutraceuticals-Vitamins A B C D E and K (structure) micronutrients such as Na, K, Ca, Cu, Zn, I -Medicinally important inorganic compounds of Al, P, As, Hg, Fe
Unit V-
Organic Pharmaceutical acids and bases: Organic Pharmaceutical acids; Agents for kidney function (Aminohippuric acid); Agents for liver function (Sulfobromophthalein); Agents for pituitary function (metyrapone) – Organic pharmaceutical bases – antioxidants, treatment of ulcer and skin diseases.
TEXTBOOKS:
- Jayashree Ghosh, Pharmaceutical chemistry, S.Chand and Company Ltd., 2006, New Delhi.
- Lakshmi S., Pharmaceutical chemistry, S.Chand& Sons, 1995, New Delhi. AshutoshKar, Medicinal chemistry, Wiley Eastern Ltd., 1993, New Delhi.
- David William & Thomas Lemke, Foyes principles of medicinal chemistry, 5th edition 2005, BI publishers.
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