INM-504 Industrial Microbiology-

Bioreactor / Fermenter- types & operation of Bioreactors, physico-chemical standards used in bioreactors, limitations of bioreactors, stages of fermentation processes, Media design for fermentation processes, Solid substrate fermentation, Fermenters (Stirred tank, bubble columns, airlift Bioreactors, Static, Submerged and agitated fermentation), advantages & disadvantages of solid substrate & liquid fermentations.

Technology of Microbial cell maintenance- steps to maintain microbial culture in an aseptic & sterile environment (how to inoculate, preserve & maintain), Strain preservation, maintenance and strain improvement by mutation of gene transfer processes.

Downstream processing- extraction, separation, concentration, recovery & purification, operations (Insulin, Vitamins, Metabolites), Industrial production of Ethyl alcohol, Acetic Acid (Vinegar), Citric acid, lactic acid, α-amylase, protease penicillin, tetracycline and vitamin B12, with reference to easily available raw materials, Production of herbal drugs.

Enzyme technology- nature of enzymes, application of enzymes, limitations of microbial cells used as catalysts in fermentation, multi-enzyme reactors, genetic engineering & protein engineering of enzymes, cloning strategy for enzymes, technology of enzyme production, use of immobilized cells and enzymes (Ca-alginate beads, polyacrylamide), industrial applications of immobilized enzymes.

Biological fuel generation- photosynthesis, sources of biomass, ethanol from biomass, methane from biomass, hydrogen, microbial recovery of petroleum.

Biotechnology in specific medical & industrial applications- Retting of jute, microbial process for immunization (Production of monoclonal antibodies), Deterioration of paper, textiles, painted surfaces and their prevention, Biofilms, microbial biopolymers, biosurfactants, Microbial culture selection with high yield potential.